abundance – Communicable Diseases Research

Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

Article

Published on 2022-09-142022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커,

Characterisation of the blood RNA host response underpinning severity in COVID-19 patients

COVID-19 환자의 중증도를 뒷받침하는 혈액 RNA 숙주 반응의 특성화

Article

Published on 2022-07-172022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료법,

[키워드] abundance addition Administered Alter Analysis asymptomatic infection biological processe biological processes Blood blood transcriptome clinical manifestations COVID-19 patient COVID-19 severity differential expression Differential expression analysis disease dysregulation Genes groups highlight host response immune dysregulation Immunoglobulin immunomodulatory Increasing individual Infection inflammatory immune response life-threatening macrophages Mild moderate neutrophil Neutrophils offer Pairwise comparison pairwise comparisons Pathway enrichment analysis Pathways performed progression Research RNA SARS-CoV-2 severe COVID-19 severe disease severity Transcriptome Treatment unique upregulation Whole blood Whole blood transcriptomics
[DOI] 10.1038/s41598-022-15547-2 PMC 바로가기 [Article Type] Article

SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent origin

SARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.

Article

Published on 2022-07-012022-09-11
Journal: Journal of medical virology
[Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology.
[DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article

Increased Abundance of Achromobacter xylosoxidans and Bacillus cereus in Upper Airway Transcriptionally Active Microbiome of COVID-19 Mortality Patients Indicates Role of Co-Infections in Disease Severity and Outcome

COVID-19 사망률 환자의 상부 기도에서 증가된 Achromobacter xylosoxidans 및 Bacillus cereus는 질병 심각도 및 결과에서 공동 감염의 역할을 나타냅니다.

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] abundance Achromobacter Actinomyce Alter Analysis Antibiotic therapy approaches Bacillus cereus Bacterial bacterial species bacterial specy Care clinical manifestation Co-infection complementary complications of COVID-19 contribute COVID-19 COVID-19 patient current disease disease outcome disease pathology disease severity disease sub-phenotype Exacerbation Factor feature functional groups highlight Holo-Seq hospital host-pathogen interactions Increased Inflammatory response Inflammatory responses Integrative analysis investigated involved isolate isolates Leptotrichia mechanism Medical care metabolic pathways microbe microbial Mild mild COVID-19 patients moderate modulate modulating Mortality nasopharyngeal nasopharyngeal RNA outcome parameters pathogen pathogen genomics Patient patients phenotype Phenotypes Phylogenetic analysis progression provide question recovered patient recovered patients reported respiratory virus respiratory virus oligo panel (RVOP) role SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 pathogenesis Sequencing severe COVID-19 severe disease severity susceptibility Symptoms the disease the patient transcript transcriptionally transcriptionally active microbial isolates. Transmissibility upper vaccination variants variants of concern VoC window
[DOI] 10.1128/spectrum.02311-21 PMC 바로가기 [Article Type] Article

Super Dominant Pathobiontic Bacteria in the Nasopharyngeal Microbiota Cause Secondary Bacterial Infection in COVID-19 Patients

비인두 미생물총의 슈퍼 우세한 병원성 박테리아는 COVID-19 환자에서 2차 박테리아 감염을 유발합니다

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum
[Category] Coronavirus, COVID19(2023년), SARS, 치료기술,

[키워드] 16S rRNA 16S rRNA gene abundance accounted Acinetobacter aggravate analyzed Bacterial Bacterial infection bacterial pneumonia bacterial specy cause collected Community composed coronavirus disease Coronavirus disease 2019 Corynebacterium Coverage COVID-19 COVID-19 infection COVID-19 patient defined difference disease severity Diversity dominant fatality genus High-throughput sequencing Infection Influenza invasive Lower respiratory tract lower respiratory tract samples microbiota Mild mild COVID-19 patients mild infection mild infections nasopharyngeal nasopharyngeal microbiota nasopharynx pathobiontic bacteria pathogen Patient patients patients with SARS-CoV-2 Pneumonia previous study respiratory infectious disease respiratory tracts responsible rRNA Sample SARS-COV-2 infection secondary secondary bacterial infection secondary bacterial infection. secondary bacterial pneumonia Seven severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients severe group severe pneumonia significantly significantly higher Staphylococcus upper upper and lower respiratory tracts upper respiratory tract variety was used
[DOI] 10.1128/spectrum.01956-21 PMC 바로가기 [Article Type] Article

Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity

COVID-19 중증도에 따른 장내 세균총 및 미생물총의 종단적 변화

Article

Published on 2022-06-242022-09-11
Journal: BMC Infectious Diseases
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] abundance alteration analyzed Bacterial Bacteroides Candida Candida albicans characteristic characterized Community comparable condition correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity decrease discharge Enterococcus Faecalibacterium Follow-up fungal group groups Gut healthy healthy individual in some increase in lactobacillus longitudinal Lower metagenomic sequencing microbial microbiota Mild mild cases mild patients MONITOR Mycobiota Mycobiota. no difference no differences Patient patients with COVID-19 positively correlated remained SARS-COV-2 infection severe cases severe COVID-19 severe group severe patients the healthy
[DOI] 10.1186/s12879-022-07358-7 PMC 바로가기 [Article Type] Article

Estimating Relative Abundance of 2 SARS-CoV-2 Variants through Wastewater Surveillance at 2 Large Metropolitan Sites, United States

미국 대도시 2곳에서 폐수 감시를 통해 2개의 SARS-CoV-2 변이체의 상대적 풍부도 추정

Article

Published on 2022-05-012022-09-11
Journal: Emerging Infectious Diseases
[Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha applied complement Concentration coronavirus coronavirus disease COVID-19 Critical Delta Delta VOC environmental monitoring estimate incidence isolate management MONITOR monitoring Mutation public health relative respiratory infections reverse transcription PCR SARS-CoV-2 SARS-CoV-2 RNA sequenced Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 United State United States vaccine-preventable diseases variant variants of concern viruses VoC VOCs wastewater zoonoses zoonoses.
[DOI] 10.3201/eid2805.212488 PMC 바로가기 [Article Type] Article

COVID-19 GPH: tracking the contribution of genomics and precision health to the COVID-19 pandemic response

COVID-19 GPH: COVID-19 대유행 대응에 대한 유전체학 및 정밀 건강의 기여도 추적

Article

Published on 2022-04-252022-09-11
Journal: BMC Infectious Diseases
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

In Vivo Hematopoietic Stem Cell Gene Therapy for SARS-CoV2 Infection Using a Decoy Receptor

유인 수용체를 사용한 SARS-CoV2 감염에 대한 생체 내 조혈 줄기 세포 유전자 치료

Article

Published on 2022-04-012022-09-11
Journal: Human gene therapy
[Category] COVID19(2023년), SARS, 변종,

[키워드] abundance Adenovirus adjust airway Antiviral antiviral efficacy approach approaches Bone marrow CD46 Cell creating cytokine cytokine production decoy decoy receptor diminishe dose effector proteins elements erythrocytes erythroid cells erythropoiesis example expressed expression Gene therapy hematopoietic Hematopoietic stem cell hematopoietic system in vivo in vivo HSC gene therapy. Infection Intervention Intravenous injection less lethal dose Lung pathology mice neutralizing capacity not affect performed Peripheral blood pilot study Prophylaxis reached receptor receptor protein reduced Regulatory resulting rhesus rhesus macaque sACE2 SARS-CoV2 SARS-CoV2 infection SARS-CoV2 vaccine SARS-CoV2 vaccines secreted shown significantly spleen STEM stem cell survived susceptible Symptoms therapy transcriptional transduced Vaccine variant Viremia while β-globin
[DOI] 10.1089/hum.2021.295 PMC 바로가기 [Article Type] Article

Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19

세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀

Article

Published on 2022-04-012022-09-11
Journal: Journal of Proteome Research
[Category] MERS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics.
[DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article